Diagnosis of Mesothelioma


Diagnosis of mesothelioma is often hard, because symptoms of mesothelioma are similar to those of a number of other conditions. Diagnosis of mesothelioma starts with the patient's medical history review. A history of exposure to asbestos may increase clinical suspicion for mesothelioma.

An examination on physical aspects is performed, followed by chest X-ray and often lung function tests. The X-ray may reveal pleural thickening commonly seen after asbestos exposure and increases suspicion of mesothelioma. A CT (or CAT) scan or an MRI is usually done. If there is a large amount of fluid, abnormal cells may be detected by cytology if this fluid is aspirated with a syringe. For pleural fluid this is done by a pleural tap or chest drain, in ascites with an paracentesis or ascitic drain and in a pericardial effusion with pericardiocentesis. While absence of malignant cells on cytology does not completely exclude mesothelioma, it makes it much more unlikely, especially if an alternative diagnosis can be made (e.g. tuberculosis, heart failure).

If cytology is positive or a plaque is regarded as suspicious, a biopsy is needed to confirm a diagnosis of mesothelioma. A doctor removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be performed in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples.

If the cancer is in the abdomen, the doctor may perform a laparoscopy. To obtain tissue for examination, the doctor makes a small incision in the abdomen and inserts a special instrument into the abdominal cavity. If these procedures do not yield enough tissue, more extensive diagnostic surgery may be necessary.

Cancer Treatment Centers


Cancer Treatment Centers of America (CTCA) is a private operator of cancer treatment hospitals and outpatient clinics providing conventional and alternative medical treatments. There are four CTCA hospitals in the United States: Midwestern Regional Medical Center in Zion, Illinois, Southwestern Regional Medical Center in Tulsa, Oklahoma, Eastern Regional Medical Center in Philadelphia, and Western Regional Medical Center in Goodyear, Arizona. An outpatient oncology clinic, Seattle Cancer Treatment and Wellness Center, is located in Seattle, Washington.

Cancer Treatment

CTCA offers traditional cancer treatments approved by the FDA, U.S. Food and Drug Administration such as surgery, radiation, chemotherapy, and stem cell transplants. Nutritional support, naturopathic medicine, mind-body medicine, spiritual counseling, and other complementary and alternative therapies are also available. CTCA promotes a model of integrating traditional treatments with complementary therapies.

CTCA promotes itself as the home of integrative and compassionate cancer care under the motto: "We never stop searching for and providing powerful and innovative therapies to heal the whole person, improve quality of life and restore hope".

CTCA Controversy

Cancer Treatment Centers of America was the subject of a Federal Trade Commission (FTC) complaint in 1993. The FTC alleged that CTCA made false claims regarding the success rates of certain cancer treatments in their promotional materials. This claim was settled in March 1996, requiring CTCA to discontinue use of any unsubstantiated claims in their advertising. CTCA is also required to have proven, scientific evidence for all statements regarding the safety, success rates, endorsements, and benefits of their cancer treatments. CTCA was also required to follow various steps in order to report compliance to the FTC per the settlement.

Watch Out! Oral Sex Cause of Throat Cancer Rise


Altering sexual practices have made throat cancer to increase in the US over the past twenty years, and experts say they fear an epidemic of the disease. The comments were made at a news conference held by the American Association for Cancer Research to discuss research into the role of the sexually transmitted human papilloma virus ( HPV) in head and neck cancer on Wednesday.

Increasing rates of HPV infection, spread through oral sex, is largely driving the rapid rise in oropharyngeal cancers, which include tumors of the throat, tonsils, and base of the tongue, said Scott Lippman, MD, who chairs the thoracic department at the University of Texas M.D. Anderson Cancer Center.

Studies of oropharyngeal tumor tissue stored 20 years ago show that only around 20% are HPV positive, Lippman said. Today it is estimated that 60% of patients are infected with the virus.

"The percentage of oropharyngeal cancers that are HPV positive is much higher now than it was 20 years ago," he said. "This is a real trend, and that is why there is concern of an epidemic given that fact that oropharyngeal cancer is increasing at an alarming rate."

Changing Face of Throat Cancer

Smoking and alcohol abuse were once considered the only major risk factors for these cancers, but this is no longer the case. American Cancer Society Chief Medical Officer Otis Brawley, MD, said as many as half of the oropharyngeal cancers diagnosed today appear to be caused by HPV infection.

"Changing sexual practices over the last 20 years, especially as they relate to oral sex, are increasing the rate of head and neck cancers and may be increasing the rates of other cancers as well," he said.

He added that there is some evidence that oral HPV infection is also a risk factor for a type of cancer of the esophagus.

"The paradigm is changing," Lippman said. "The types of patients we are seeing now with oropharyngeal cancers are not the patients we have classically seen who were older, smokers, and have lots of other problems. These are young people, executives, a whole different population."

Oral Sex Not Safe Sex

The experts agreed that it is critical for the public to understand that oral sex doesn’t equal safe sex. The message was unofficially promoted in the early days of the HIV epidemic and it is still widely believed by many, especially teens.

Studies suggest that teens are often unaware of the risks associated with unprotected oral sex, including the transmission of HPV, chlamydia, and gonorrhea. "There is a huge public health message here," Brawley said.

Do You Have These Symptoms of Mesothelioma?


Symptoms of mesothelioma might not be felt till 20-50 years after exposure to asbestos. Cough, shortness of breath, and chest pain due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.

Weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity) are symptoms of peritoneal mesothelioma. Other symptoms of peritoneal mesothelioma are bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.

These symptoms may be caused by mesothelioma or by other, less serious conditions.

Mesothelioma that affects the pleura can cause these signs and symptoms:

* Chest wall pain
* Pleural effusion, or fluid surrounding the lung
* Shortness of breath
* Fatigue or anemia
* Wheezing, hoarseness, or cough
* Blood in the sputum (fluid) coughed up (hemoptysis)

In severe cases, the person may have many tumor masses. The individual may develop a pneumothorax, or collapse of the lung. The disease may metastasize, or spread, to other parts of the body.

Tumors that affect the abdominal cavity often do not cause symptoms until they are at a late stage. Symptoms include:

* Abdominal pain
* Ascites, or an abnormal buildup of fluid in the abdomen
* A mass in the abdomen
* Problems with bowel function
* Weight loss

In severe cases of the disease, the following signs and symptoms may be present:

* Blood clots in the veins, which may cause thrombophlebitis
* Disseminated intravascular coagulation, a disorder causing severe bleeding in many body organs
* Jaundice, or yellowing of the eyes and skin
* Low blood sugar level
* Pleural effusion
* Pulmonary emboli, or blood clots in the arteries of the lungs
* Severe ascites

A mesothelioma does not usually spread to the bone, brain, or adrenal glands. Pleural tumors are usually found only on one side of the lungs.

Have You Done Any of These 4 Healthy Habits for Cutting Disease Risk?


Never smoke. Take a walk. Don't eat junk food. Watch your waistline.

You probably have heard the advice many times before. But did you know that if you follow all four of these healthy habits together, you could decrease your chances of developing some of the most common and deadly chronic diseases by nearly 80%?

A study analyzing the health, lifestyles, and diet of 23,513 35 to 65 years old German showed that those who had more healthy habits were much less likely to get diseases such as cancer, diabetes, and heart disease.

The analysis included a detailed look at each person's body weight and height, disease background, food frequency, and how well they followed these four healthy lifestyle habits over the study period:

* Never smoked
* Exercised at least 3.5 hours per week
* Maintained a body mass index (BMI) under 30
* Followed a diet high in fruits, vegetables, and whole-grain breads, and limited in meats

Only 9% of the people in the study said they followed all four habits, but most of the people had at least one healthy habit.

After adjusting for risk factors that might influence the development of disease, the researchers learned that those who followed all four healthy habits had a 78% lower risk of developing a chronic condition such as diabetes, cardiovascular disease, or cancer compared to those who reported none of the healthy habits.

Specifically, in the study, all four of the healthy habits combined were linked to a:

* 93% lower risk of type 2 diabetes
* 81% lower risk of heart attack
* 50% lower risk of stroke
* 36% lower risk of cancer

Researchers say it's important to adopt and teach healthy habits early in life. Their findings "reinforce current public health recommendations to avoid smoking, to maintain a healthy weight, to engage in physical activity appropriately and to eat adequate amounts of fruits and vegetables and foods containing whole grains and to partake of red meat prudently," study author Earl S. Ford, MD, MPH, of the CDC, and colleagues write.

The following habits may help you lower your risk of developing chronic diseases. They are listed in order of largest to smallest impact on disease risk, as determined by the recent study.

1. Maintain a healthy weight. Your body mass index should be lower than 30.
2. Never smoke. (But if you already do, you should quit.)
3. Get at least 3.5 hours of exercise every week.
4. Follow a healthy diet. Ask your doctor for recommendations.

Mesothelioma: What Is It?


Mesothelioma is a type of cancer that is mostly caused by exposure to asbestos. When people have this disease, their malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart, the pericardium (a sac that surrounds the heart) or tunica vaginalis.

People with mesothelioma have usually worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a person who worked with asbestos can put a person at risk for developing mesothelioma. There is no association between mesothelioma and smoking, but smoking greatly increases risk of other asbestos-induced cancer. Compensation via asbestos funds or lawsuits is an important issue in mesothelioma.

The mesothelioma symptoms include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be applied to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.

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